Custom Peptides
Cayman Chemical Desvaleryl Valsartn 10mg
A potential impurity found in commercial preparations of valsartan; a degradation product formed under acidic conditions
Cayman Chemical MurIdeoxycholIc AcId 10mg
A secondary bile acid produced from α-muricholic acid and β-muricholic acid; metabolite of lithocholic acid; prevents gallstones in hamsters; does not resolve gallstones in prairie dogs and induces formation of insoluble bile acid salt gallstones; rapidly absorbed in humans
Cayman Chemical 3-Methylcrotonyl GlycIn 10mg
A metabolite; found in urine of patients with 3-methycrotonyl glycinuria; inhibits CO2 production and mitochondrial complex II-III and creatine kinase activity in rat cerebral cortex preparations in a concentration-dependent manner; inhibits the Na+/K+-ATPase in purified synaptic membranes from rat cerebrum
Cayman Chemical 7methoxy ApIgenInIdInCLOr 10mg
A 3-deoxyanthocyanin; active against radial growth of G. sorghi and spore germination of P. oryzae (IC50 = 50 ppm for both)
Cayman Chemical 6-DeoxypencIclovIr 10mg
An inactive metabolite of famciclovir; a precursor metabolite to penciclovir; has been used in the synthesis of prodrug forms of penciclovir
Cayman Chemical SBE 13hydrochlorIde 10mg
A potent inhibitor of Plk1(IC50 = 0.2 nM) that targets the inactive conformation of the enzyme; exhibits no activity against aurora A kinase and less effectively inhibites Plk2 (IC50 > 66 µM) and Plk3 (IC50 = 875 nM); induces cell cycle arrest, reduces cell proliferation, and induces apoptosis
Cayman Chemical AzelastInhydrochlorIde 10mg
A histamine H1 receptor antagonist (Ki = 1.26 nM); selective for histamine H1 over histamine H3 receptors (Ki = 158.49 nM), as well as α1A- and α1B-adrenergic receptors (Ki = 50.12 nM for both); reduces nose rubbing, sneezing, and nasal mucosa expression of IL-4 in a dust mite-induced mouse model of allergic rhinitis at 0.14 UG/animal; reduces infection by a lentivirus pseudotyped with SARS-CoV-2 spike glycoprotein in HEK293 cells expressing ACE2 at 7 UG/ml
Cayman Chemical Alcaftadn 10mg
A H1 histamine receptor antagonist (IC50 = 8.6 nM) with anti-inflammatory and mast cell stabilizing effects; reduces edema and erythema in a guinea pig model of allergic conjunctivitis (ED50 = 0.1 mg/kg); has been used in clinical formulations in eye drops for treatment of ocular itching associated with allergic conjunctivitis
Cayman Chemical VInorelbIntartrate 10mg
An inhibitor of microtubule polymerization that blocks mitosis at the metaphase/anaphase transition, preventing HeLa cell proliferation (IC50 = 1.25 nM)
Cayman Chemical UCL-TRO-1938 10mg
An allosteric PI3Kα activator; It binds to PI3Kα in an SPR assay (Kd = 36 µM) and induces PI3Kα activation in a cell-free assay at 25 and 50 µM; increases PtdIns-(3,4,5)-P3 and phosphorylated Akt levels in MEFs (EC50s = 5 and 2-4 µM, respectively); increases tissue survival and decreases infarct size in perfused rat hearts; reduces infarct size in a mouse model of LAD coronary artery occlusion-induced ischemia-reperfusion injury at 10 mg/kg; increases the number of motor neurons and innervation of neuromuscular junctions in a rat model of sciatic nerve crush injury
Cayman Chemical N-Desbutyl Drondaronhydro 10mg
An active metabolite of dronedarone; inhibits T3 binding to TRα1 and TRβ1 (IC50s = 59 and 280 µM for the chicken and human receptors, respectively); inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide hydrolase-mediated formation of 14,15-DHET from 14,15-EET (IC50s = 1.59 and 2.73 µM, respectively, in cell-free assays); decreases intracellular ATP levels in H9c2 rat cardiomyocytes (IC50 = 1.07 µM); inhibits mitochondrial complex I and mitochondrial complex II activities in isolated rat heart mitochondria (IC50s = 11.94 and 24.54 µM, respectively)
Cayman Chemical Lnnamvr 10mg
An inhibitor of influenza neuraminidases and an active metabolite of laninamivir octanoate; inhibits the neuraminidases from influenza A H1N1, H2N2, and H3N2 strains (mean IC50s = 2.49, 11.4, and 16.7 nM, respectively) and influenza B Victoria and Yamagata strains (mean IC50s = 18.9 nM for both); increases survival in a mouse model of lethal influenza H1N1 infection when administered intranasally at 69 UG/kg
Cayman Chemical 7-DemethylsuberosIn 10mg
A prenylated coumarin with anti-inflammatory and neuroprotective activities; inhibits TPA- and A23187-induced histamine release from HMC-1 cells at 10 µM; protects against glutamate-induced cytotoxicity in primary rat cortical cells at 0.1-10 µM
Cayman Chemical Arg9trIfluoroacetAT salt 10mg
A cationic cell-penetrating peptide; has been used to deliver various cargo to cells, including fluorescent proteins and plasmids; protects primary rat cortical neurons from glutamate-induced excitotoxicity at 5 and 10 µM
Cayman Chemical aContoxIn PnIAtrIfluoroac 10mg
A peptide antagonistic of α7 and α3β2-subunit containing nAChRs (IC50s = 62.7 and 7.9 nM, respectively); inhibits tumor growth and increases survival in an Ehrlich murine spontaneous adenocarcinoma model at 0.1 nmole/kg in combination with baicalein